Garbaccio, Robert M.: search on Z-Library

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1

The Impact of Chemical Probes in Drug Discovery: A Pharmaceutical Industry Perspective

Garbaccio, Robert M., Parmee, Emma R.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 638 KB

english, 2016

2

Optimization of an α-(Amino acid)- N -carboxyanhydride polymerization using the high vacuum technique: Examining the effects of monomer concentration, polymerization kinetics, polymer molecular weight, and monomer purity

Kowtoniuk, Robert A., Pei, Tao, DeAngelo, Caitlin M., Waldman, Jacob H., Guidry, Erin N., Williams, J. Michael, Garbaccio, Robert M., Barrett, Stephanie E.

Journal:

Journal of Polymer Science Part A: Polymer Chemistry

Year:

2014

Language:

english

File:

PDF, 270 KB

english, 2014

3

Novel Endosomolytic Poly(amido amine) Polymer Conjugates for Systemic Delivery of siRNA to Hepatocytes in Rodents and Nonhuman Primates

Parmar, Rubina Giare, Poslusney, Micheal, Busuek, Marina, Williams, J. Michael, Garbaccio, Robert, Leander, Karen, Walsh, Eileen, Howell, Bonnie, Sepp-Lorenzino, Laura, Riley, Sean, Patel, Mihir, Kemp

Journal:

Bioconjugate Chemistry

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

4

Regioselective Inverse Electron Demand Diels−Alder Reactions of N -Acyl 6-Amino-3-(methylthio)-1,2,4,5-tetrazines

Boger, Dale L., Schaum, Robert P., Garbaccio, Robert M.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 253 KB

english, 1998

5

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP

Robert M. Garbaccio, Edward S. Tasber, Lou Anne Neilson, Paul J. Coleman, Mark E. Fraley, Christy Olson, Jeff Bergman, Maricel Torrent, Carolyn A. Buser, Keith Rickert, Eileen S. Walsh, Kelly Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 186 KB

english, 2007

6

Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis

Layton, Mark E., Reif, Alexander J., Hartingh, Timothy J., Rodzinak, Kevin, Dudkin, Vadim, Wang, Cheng, Arrington, Ken, Kelly, Michael J., Garbaccio, Robert M., O’Brien, Julie A., Magliaro, Brian C.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 679 KB

english, 2016

7

Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol

Kana Yamamoto, Robert M. Garbaccio, Shawn J. Stachel, David B. Solit, Gabriela Chiosis, Neal Rosen, Samuel J. Danishefsky

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 141 KB

english, 2003

8

An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents

Barrett, Stephanie E., Abrams, Marc T., Burke, Rob, Carr, Brian A., Crocker, Louis S., Garbaccio, Robert M., Howell, Bonnie J., Kemp, Eric A., Kowtoniuk, Robert A., Latham, Andrew H., Leander, Karen R

Journal:

International Journal of Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 1.40 MB

english, 2014

9

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, Robert M. Garbaccio, Kenneth L. Arrington, William F. Hoffman, Edward S. Tasber, Paul J. Coleman, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Christine Fernandes, Michael D. Sch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

10

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Robert M. Garbaccio, Mark E. Fraley, Edward S. Tasber, Christy M. Olson, William F. Hoffman, Kenneth L. Arrington, Maricel Torrent, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Michael D. Schabe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

11

Thermodynamic equilibration of dihydropyridone enolates: application to the total synthesis of (+/−)-epiuleine

Edward S. Tasber, Robert M. Garbaccio

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

12

Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation

Dale L. Boger, Robert M. Garbaccio

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 1.45 MB

english, 1997

13

Discovery of Allosteric Inhibitors of Kinesin Spindle Protein (KSP) for the Treatment of Taxane-Refractory Cancer: MK-0731 and Analogs

D. Cox, Christopher, M. Garbaccio, Robert

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 528 KB

english, 2010

14

Concise Asymmetric Syntheses of Radicicol and Monocillin I

Garbaccio, Robert M., Stachel, Shawn J., Baeschlin, Daniel K., Danishefsky, Samuel J.

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 103 KB

english, 2001

15

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

Antonella Converso, Timothy Hartingh, Robert M. Garbaccio, Edward Tasber, Keith Rickert, Mark E. Fraley, Youwei Yan, Constantine Kreatsoulas, Steve Stirdivant, Bob Drakas, Eileen S. Walsh, Kelly Hamil

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.56 MB

english, 2009

16

Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride

Dale L. Boger, Christopher W. Boyce, Robert M. Garbaccio, Mark Searcey

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 295 KB

english, 1998

17

Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues

Chunze Li, Bing Lu, Robert M. Garbaccio, Edward S. Tasber, Mark E. Fraley, George D. Hartman, Jingjing Ye, Jane C. Harrelson, Thomayant Prueksaritanont

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 516 KB

english, 2010

18

Synthesis and Evaluation of CC-1065 and Duocarmycin Analogues Incorporating the Iso-CI and Iso-CBI Alkylation Subunits: Impact of Relocation of the C-4 Carbonyl

Boger, Dale L., Garbaccio, Robert M., Jin, Qing

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 534 KB

english, 1997

19

CC-1065 and the Duocarmycins: Synthetic Studies

Boger, Dale L., Boyce, Christopher W., Garbaccio, Robert M., Goldberg, Joel A.

Journal:

Chemical Reviews

Year:

1997

Language:

english

File:

PDF, 4.61 MB

english, 1997

20

Preface

Garbaccio, Robert M., Johnson, Douglas S., Hong, Jiyong, Disney, Matthew D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 149 KB

english, 2015

21

Thermodynamic Equilibration of Dihydropyridone Enolates: Application to the Total Synthesis of (+/-)-Epiuleine.

Edward S. Tasber, Robert M. Garbaccio

Journal:

Year:

2004

File:

PDF, 105 KB

2004

22

ChemInform Abstract: Shape-Dependent Catalysis: Insights into the Source of Catalysis for the CC-1065 and Duocarmycin DNA Alkylation Reaction

Dale L. Boger, Robert M. Garbaccio

Journal:

Year:

2000

File:

PDF, 25 KB

2000

23

Are the Duocarmycin and CC-1065 DNA Alkylation Reactions Acid-Catalyzed? Solvolysis pH−Rate Profiles Suggest They Are Not

Boger, Dale L., Garbaccio, Robert M.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 52 KB

english, 1999

24

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Paul J. Coleman, John D. Schreier, Christopher D. Cox, Mark E. Fraley, Robert M. Garbaccio, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Robert B. Lobell, Keith Rickert, Weikang Tao, Ronald E. D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

25

A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation

Boger, Dale L., Garbaccio, Robert M.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 571 KB

english, 1999

26

Diastereoselectivity in cyclopropanation and epoxidation reactions of chiral (E)-crotylsilanes: Asymmetric synthesis of substituted tetrahydrofurans

James S. Panek, Robert M. Garbaccio, Nareshkumar F. Jain

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 278 KB

english, 1994

27

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Converso, Antonella, Hartingh, Timothy, Fraley, Mark E., Garbaccio, Robert M., Hartman, George D., Huang, Shaei Y., Majercak, John M., McCampbell, Alexander, Na, Sang Jin, Ray, William J., Savage, Mar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 611 KB

english, 2014

28

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Edward J. Brnardic, Robert M. Garbaccio, Mark E. Fraley, Edward S. Tasber, Justin T. Steen, Kenneth L. Arrington, Vadim Y. Dudkin, George D. Hartman, Steven M. Stirdivant, Bob A. Drakas, Keith Rickert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 466 KB

english, 2007

29

Size controlled synthesis of ornithine-based polypeptides by ring-opening polymerization of α-(amino acid)- N -carboxyanhydrides

Pei, Tao, Liao, Jing, Williams, J. Michael, Xiang, Rong, Garbaccio, Robert M., Barrett, Stephanie E., Guidry, Erin N.

Journal:

Journal of Polymer Science Part A: Polymer Chemistry

Year:

2016

Language:

english

File:

PDF, 314 KB

english, 2016

30

Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol

Kana Yamamoto, Robert M. Garbaccio, Shawn J. Stachel, David B. Solit, Gabriela Chiosis, Neal Rosen, Samuel J. Danishefsky

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 141 KB

english, 2003

31

ChemInform Abstract: Concise Asymmetric Syntheses of Radicicol and Monocillin I.

Robert M. Garbaccio, Shawn J. Stachel, Daniel K. Baeschlin, Samuel J. Danishefsky

Journal:

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

32

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Cox, Christopher D., Coleman, Paul J., Breslin, Michael J., Whitman, David B., Garbaccio, Robert M., Fraley, Mark E., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Schaber, Michael D., Lobell,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1010 KB

english, 2008

33

Shape-Dependent Catalysis: Insights into the Source of Catalysis for the CC-1065 and Duocarmycin DNA Alkylation Reaction

Boger, Dale L., Garbaccio, Robert M.

Journal:

Accounts of Chemical Research

Year:

1999

Language:

english

File:

PDF, 626 KB

english, 1999

34

ChemInform Abstract: A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation

Dale L. Boger, Robert M. Garbaccio

Journal:

Year:

2000

File:

PDF, 25 KB

2000

35

Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

Christopher D. Cox, Michael J. Breslin, David B. Whitman, Paul J. Coleman, Robert M. Garbaccio, Mark E. Fraley, Matthew M. Zrada, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Robert B. Lobell, W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 179 KB

english, 2007

36

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP

Keith W. Rickert, Michael Schaber, Maricel Torrent, Lou Anne Neilson, Edward S. Tasber, Robert Garbaccio, Paul J. Coleman, Diane Harvey, Yun Zhang, Yi Yang, Gary Marshall, Ling Lee, Eileen S. Walsh, K

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 1.22 MB

english, 2008

37

ChemInform Abstract: Efficient Asymmetric Synthesis of Radicicol Dimethyl Ether: A Novel Application of Ring-Forming Olefin Metathesis.

Robert M. Garbaccio, Samuel J. Danishefsky

Journal:

Year:

2001

File:

PDF, 32 KB

2001

38

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Edward J. Brnardic, Mark E. Fraley, Robert M. Garbaccio, Mark E. Layton, John M. Sanders, Chris Culberson, Marlene A. Jacobson, Brian C. Magliaro, Pete H. Hutson, Julie A. O’Brien, Sarah L. Huszar, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 984 KB

english, 2010

39

ChemInform Abstract: Iterative Assembly of Glycals and Glycal Derivatives: Synthesis of Glycosylated Natural Products and Complex Oligosaccharides

Lawrence J. Williams, Robert M. Garbaccio, Samuel J. Danishefsky

Journal:

Year:

2001

File:

PDF, 26 KB

2001

40

Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase

Robert M. Garbaccio, Shaei Huang, Edward S. Tasber, Mark E. Fraley, Youwei Yan, Sanjeev Munshi, Mari Ikuta, Lawrence Kuo, Constanine Kreatsoulas, Steve Stirdivant, Bob Drakas, Keith Rickert, Eileen S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 261 KB

english, 2007

41

Recent advances in medicinal chemistry

Brian S.J. Blagg, Douglas S. Johnson, Robert M. Garbaccio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 109 KB

english, 2011

42

Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates

Barrett, Stephanie E., Burke, Rob S., Abrams, Marc T., Bason, Carol, Busuek, Marina, Carlini, Edward, Carr, Brian A., Crocker, Louis S., Fan, Haihong, Garbaccio, Robert M., Guidry, Erin N., Heo, Jun H

Journal:

Journal of Controlled Release

Year:

2014

Language:

english

File:

PDF, 2.05 MB

english, 2014

43

Synthesis and Evaluation of a Series of C3-Substituted CBI Analogues of CC-1065 and the Duocarmycins

Boger, Dale L., Brunette, Steven R., Garbaccio, Robert M.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 164 KB

english, 2001

44

Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor

Garbaccio, Robert M., Brnardic, Edward J., Fraley, Mark E., Hartman, George D., Hutson, Pete H., O'Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Small,

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1009 KB

english, 2010

45

ChemInform Abstract: Synthesis and Evaluation of a Series of C3-Substituted CBI Analogues of CC-1065 and the Duocarmycins.

Dale L. Boger, Steven R. Brunette, Robert M. Garbaccio

Journal:

Year:

2001

File:

PDF, 37 KB

2001

46

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

Shaei Huang, Robert M. Garbaccio, Mark E. Fraley, Justin Steen, Constantine Kreatsoulas, George Hartman, Steve Stirdivant, Bob Drakas, Keith Rickert, Eileen Walsh, Kelly Hamilton, Carolyn A. Buser, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

47

Reversed and Sandwiched Analogs of Duocarmycin SA: Establishment of the Origin of the Sequence-Selective Alkylation of DNA and New Insights into the Source of Catalysis

Boger, Dale L., Bollinger, Bernd, Hertzog, Donald L., Johnson, Douglas S., Cai, Hui, Mésini, Philippe, Garbaccio, Robert M., Jin, Qing, Kitos, Paul A.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 530 KB

english, 1997

48

Efficient Asymmetric Synthesis of Radicicol Dimethyl Ether: A Novel Application of Ring-Forming Olefin Metathesis

Garbaccio, Robert M., Danishefsky, Samuel J.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 51 KB

english, 2000

49

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI

Pero, Joseph E., Rossi, Michael A., Kelly, Michael J., Lehman, Hannah D. G. F., Layton, Mark E., Garbaccio, Robert M., O’Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillg

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 599 KB

english, 2016

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